Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Curr Drug Targets. 2013 Jun;14(7):768-76. doi: 10.2174/1389450111314070006.
This review examines the growing literature on the role of peroxisome proliferator-activated receptors (PPARs) in addiction. There are two subtypes of PPAR receptors that have been studied in addiction: PPAR-α and PPAR-γ. The role of each PPAR subtype in common models of addictive behavior, mainly pre-clinical models, is summarized. In particular, studies are reviewed that investigated the effects of PPAR-α agonists on relapse, sensitization, conditioned place preference, withdrawal and drug intake, and effects of PPAR-γ agonists on relapse, withdrawal and drug intake. Finally, studies that investigated the effects of PPAR agonists on neural pathways of addiction are reviewed. Taken together these preclinical data indicate that PPAR agonists are promising new medications for drug addiction treatment.
这篇综述考察了关于过氧化物酶体增殖物激活受体（PPARs）在成瘾中的作用的不断增长的文献。有两种亚型的 PPAR 受体已在成瘾中进行了研究：PPAR-α和 PPAR-γ。总结了每种 PPAR 亚型在常见成瘾行为模型中的作用，主要是临床前模型。特别回顾了研究 PPAR-α激动剂对复发、敏化、条件性位置偏爱、戒断和药物摄入的影响，以及 PPAR-γ激动剂对复发、戒断和药物摄入的影响。最后，综述了研究 PPAR 激动剂对成瘾神经通路影响的研究。这些临床前数据表明，PPAR 激动剂是治疗药物成瘾的有前途的新药。
