三组分环化反应 Sc(OTf)3 催化的三组分环化反应，包括芳胺、β,γ-不饱和α-酮酯和 1,3-二羰基化合物，用于合成高度取代的 1,4-二氢吡啶和四氢吡啶。
Sc(OTf)3-catalyzed three-component cyclization of arylamines, β,γ-unsaturated α-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines.
机构信息
Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.
出版信息
J Org Chem. 2013 Jun 7;78(11):5751-5. doi: 10.1021/jo400578m. Epub 2013 May 16.
PMID:23614840
Abstract
A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, β,γ-unsaturated α-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.
摘要
开发了一种由 Sc(OTf)3 催化的芳胺、β,γ-不饱和α-酮酯和 1,3-二羰基化合物的三组分环化反应，用于合成高度取代的 1,4-二氢吡啶和带有季碳中心的稠合双环四氢吡啶。
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