Department of Ophthalmology, University Medical Center, DE-55131 Mainz, Germany.
Ophthalmologica. 2013;229(4):227-34. doi: 10.1159/000350553. Epub 2013 Apr 24.
The main objective of this analysis was to assess the impact of severity of disease on the quality of life (QoL) of patients with ocular hypertension (OHT) and early, moderate, or advanced primary open-angle glaucoma (POAG).
This multicenter study was conducted at 2 university hospitals and 13 ophthalmology practices in Germany. QoL data were assessed by the Health Utility Index (HUI3) and the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25).
154 patients (17.5% OHT, 27.9% early, 22.7% moderate, and 31.8% advanced POAG) were included. The HUI3 scores for OHT, early, moderate, and advanced POAG were 0.87 ± 0.09, 0.85 ± 0.15, 0.75 ± 0.23, and 0.58 ± 0.32, respectively. Compared to a normal population matched by age and gender, for moderate and severe POAG a difference of -0.06 ± 0.24 and -0.19 ± 0.28, respectively, was observed. NEI-VFQ-25 scores illustrate different dimensions of the impact on QoL; reduced peripheral vision or difficulties to drive a car were more crucial to glaucoma patients than social factors.
The key difference for QoL impairment in glaucoma lies between OHT/early POAG versus moderate/severe POAG, hence every possible effort needs to be made to prevent disease progression over this threshold.
本分析的主要目的是评估疾病严重程度对眼压升高（OHT）和早期、中期或晚期原发性开角型青光眼（POAG）患者生活质量（QoL）的影响。
这项多中心研究在德国的 2 所大学医院和 13 家眼科诊所进行。通过健康效用指数（HUI3）和 25 项国家眼科研究所视觉功能问卷（NEI-VFQ-25）评估 QoL 数据。
共纳入 154 例患者（17.5%为 OHT，27.9%为早期 POAG，22.7%为中期 POAG，31.8%为晚期 POAG）。OHT、早期、中期和晚期 POAG 的 HUI3 评分分别为 0.87±0.09、0.85±0.15、0.75±0.23 和 0.58±0.32。与年龄和性别匹配的正常人群相比，中重度 POAG 的差异分别为-0.06±0.24 和-0.19±0.28。NEI-VFQ-25 评分显示了对 QoL 影响的不同维度；与社会因素相比，青光眼患者的周边视力下降或驾驶困难对 QoL 的影响更为关键。
青光眼患者 QoL 受损的关键差异在于 OHT/早期 POAG 与中重度 POAG 之间，因此需要尽一切努力防止疾病在这一阈值上进展。
