Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel.
J Neurophysiol. 2013 Jul;110(2):279-85. doi: 10.1152/jn.00834.2012. Epub 2013 Apr 24.
Long-term effects of stress during pregnancy on brain and behavior have been analyzed extensively in recent years. These effects include changes in emotional behavior, a reduction in learning capacity, and ability to generate long-term potentiation (LTP) in the offspring. In earlier studies, we and others have described a difference in ability to express LTP in dorsal and ventral sectors of the hippocampus (DH and VH, respectively) and its modification by prior stress. We now found that norepinephrine (NE) facilitated conversion of short-term potentiation to LTP in the normal DH but not in VH. Prenatal stress (PS) switched the locus of the facilitating action of NE from the DH to the VH. The effects of NE are likely to be mediated by activation of calcium stores. PS also facilitated (S)-3,5-dihydroxyphenylglycine hydrate (DHPG)-induced LTD in the VH, assumed to be mediated by release of calcium from stores. These observations have important implications for the role of the hippocampus in cognitive and emotional memories.
近年来，人们广泛研究了孕期压力对大脑和行为的长期影响。这些影响包括情绪行为的变化、学习能力的降低，以及后代长时程增强（LTP）能力的丧失。在早期的研究中，我们和其他人描述了海马体背侧和腹侧（DH 和 VH）LTP 表达能力的差异，以及其受先前压力的影响。我们现在发现，去甲肾上腺素（NE）促进了正常 DH 中短期增强向 LTP 的转化，但不能促进 VH 中短期增强向 LTP 的转化。产前应激（PS）将 NE 的促进作用的位置从 DH 转移到 VH。NE 的作用可能是通过钙库的激活来介导的。PS 还促进了（S）-3,5-二羟基苯甘氨酸水合物（DHPG）诱导的 VH 中的 LTD，假定是通过从库中释放钙来介导的。这些观察结果对海马体在认知和情感记忆中的作用具有重要意义。
