Miliou Athina, Papaleonidopoulos Vassilis, Trompoukis George, Papatheodoropoulos Costas
Laboratory of Neurophysiology, Department of Medicine, University of Patras, Rion, Greece.
IBRO Neurosci Rep. 2021 Aug 4;11:64-72. doi: 10.1016/j.ibneur.2021.07.002. eCollection 2021 Dec.
Recent evidence shows a greater facilitating effect of beta-adrenergic receptors (β-ARs) on long-term synaptic plasticity in the ventral versus the dorsal hippocampus. Here, using field potentials from the CA1 area and a ten-pulse stimulation train of varying frequency we show that activation of β-ARs by isoproterenol preferentially facilitates the output from the dorsal hippocampus at the frequency range of 3-40 Hz without affecting short-term synaptic plasticity. Furthermore, isoproterenol increases basal synaptic transmission in the dorsal hippocampus only and enhances basal neuronal excitation more in the dorsal than the ventral hippocampus. These results suggest that β-AR-modulation of short-term neuronal dynamics differs along the longitudinal axis of the hippocampus, thereby contributing to functional specialization along the same axis.
最近的证据表明，β-肾上腺素能受体（β-ARs）对腹侧海马体长期突触可塑性的促进作用比对背侧海马体更强。在此，我们利用来自CA1区的场电位和不同频率的十脉冲刺激序列，发现异丙肾上腺素激活β-ARs在3 - 40Hz频率范围内优先促进背侧海马体的输出，而不影响短期突触可塑性。此外，异丙肾上腺素仅增加背侧海马体的基础突触传递，且在背侧海马体中比在腹侧海马体中更能增强基础神经元兴奋性。这些结果表明，β-ARs对短期神经元动力学的调节沿海马体的纵轴存在差异，从而导致沿同一轴的功能特化。
