Warrington S J, Sinclair A J, Johnston A
Charterhouse Clinical Research Unit, London, UK.
J Int Med Res. 1990;18 Suppl 2:3B-9B.
The effects of single doses of a combination of 20 mg frusemide and 2.5 mg amiloride, of 20 mg frusemide and of placebo on plasma and urinary electrolytes were assessed in healthy volunteers using a randomized, crossover study. The combination significantly (P less than 0.001) increased the urinary volume compared with frusemide alone or placebo. Mean total urinary sodium was also significantly (P less than 0.001) increased by frusemide/amiloride compared with both frusemide and placebo. Mean total potassium excretion was reduced significantly (P less than 0.01) by frusemide/amiloride but total magnesium excretion was not significantly affected. The effects of frusemide/amiloride on plasma sodium, magnesium and potassium were similar to those of placebo. It is concluded that frusemide/amiloride has a greater diuretic and natriuretic effect than frusemide alone and does not increase potassium loss.
采用随机交叉研究，在健康志愿者中评估了单剂量20毫克速尿与2.5毫克阿米洛利联合用药、20毫克速尿及安慰剂对血浆和尿液电解质的影响。与单用速尿或安慰剂相比，联合用药显著（P<0.001）增加了尿量。与速尿和安慰剂相比，速尿/阿米洛利也显著（P<0.001）增加了尿钠总量。速尿/阿米洛利显著（P<0.01）减少了钾的总排泄量，但对镁的总排泄量无显著影响。速尿/阿米洛利对血浆钠、镁和钾的影响与安慰剂相似。结论是，速尿/阿米洛利比单用速尿具有更强的利尿和利钠作用，且不会增加钾的流失。
