Korn A, Eichler H G, Gasic S
Int J Clin Pharmacol Ther Toxicol. 1986 May;24(5):262-4.
Ceftriaxone, a recently developed cephalosporin significantly reduced the diuretic activity of frusemide in rats. For this reason and because an interaction of unknown mechanism is well established between frusemide and some cephalosporins, we studied the interference of ceftriaxone with the diuretic effect of frusemide in healthy volunteers. Twelve subjects received frusemide (40 mg p.o.) or placebo in combination with ceftriaxone (2 g i.v.) or saline on 4 different days (cross-over, randomized, single-blind study). Urine was collected in small portions during 24 hours after medication and analyzed for volume, osmolality, Na+, K+, Cl- and creatinine concentration. Ceftriaxone had neither an effect on basal urinary output and electrolyte excretion nor on the specific diuretic action of frusemide.
头孢曲松，一种最近研发的头孢菌素，能显著降低速尿在大鼠体内的利尿活性。鉴于此，且由于速尿与某些头孢菌素之间已明确存在机制不明的相互作用，我们研究了头孢曲松对健康志愿者中速尿利尿作用的干扰。12名受试者在4个不同日期接受速尿（口服40毫克）或安慰剂，同时静脉注射头孢曲松（2克）或生理盐水（交叉、随机、单盲研究）。用药后24小时内分多次收集尿液，分析其体积、渗透压、钠、钾、氯和肌酐浓度。头孢曲松对基础尿量和电解质排泄以及速尿的特定利尿作用均无影响。
