在速尿诱导大鼠利尿期间，氨氯吡咪对肾脏镁清除率呈剂量依赖性降低。
Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats.
作者信息
Devane J, Ryan M P
出版信息
Br J Pharmacol. 1983 Nov;80(3):421-8. doi: 10.1111/j.1476-5381.1983.tb10711.x.
Abstract
The effects of the potassium-sparing diuretic, amiloride, on fractional magnesium excretion were investigated at four doses (0.02, 0.08, 0.20 and 2.00 mg kg-1 h-1) during frusemide-induced diuresis. Amiloride caused a dose-dependent reduction in the fractional excretion of both magnesium and potassium, whereas the effects of amiloride, over the same dose range, on fractional sodium and calcium excretion were not dose-dependent. The results indicate that amiloride exerted a specific renal action to alter magnesium and potassium transport dissociated from effects on sodium excretion.
摘要
在速尿诱导利尿期间，研究了保钾利尿剂阿米洛利在四种剂量（0.02、0.08、0.20和2.00mg kg-1 h-1）下对镁排泄分数的影响。阿米洛利使镁和钾的排泄分数呈剂量依赖性降低，而在相同剂量范围内，阿米洛利对钠和钙排泄分数的影响不呈剂量依赖性。结果表明，阿米洛利发挥了一种特定的肾脏作用，改变了镁和钾的转运，且这种作用与对钠排泄的影响无关。
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