在速尿诱导大鼠利尿期间，氨氯吡咪对肾脏镁清除率呈剂量依赖性降低。
Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats.
作者信息
Devane J, Ryan M P
出版信息
Br J Pharmacol. 1983 Nov;80(3):421-8. doi: 10.1111/j.1476-5381.1983.tb10711.x.
Abstract
The effects of the potassium-sparing diuretic, amiloride, on fractional magnesium excretion were investigated at four doses (0.02, 0.08, 0.20 and 2.00 mg kg-1 h-1) during frusemide-induced diuresis. Amiloride caused a dose-dependent reduction in the fractional excretion of both magnesium and potassium, whereas the effects of amiloride, over the same dose range, on fractional sodium and calcium excretion were not dose-dependent. The results indicate that amiloride exerted a specific renal action to alter magnesium and potassium transport dissociated from effects on sodium excretion.
摘要
在速尿诱导利尿期间，研究了保钾利尿剂阿米洛利在四种剂量（0.02、0.08、0.20和2.00mg kg-1 h-1）下对镁排泄分数的影响。阿米洛利使镁和钾的排泄分数呈剂量依赖性降低，而在相同剂量范围内，阿米洛利对钠和钙排泄分数的影响不呈剂量依赖性。结果表明，阿米洛利发挥了一种特定的肾脏作用，改变了镁和钾的转运，且这种作用与对钠排泄的影响无关。
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本文引用的文献
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The effect of diuretics on lymphocyte magnesium and potassium.利尿剂对淋巴细胞镁和钾的影响。
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The mechanism of action of amipramizide.阿米普明的作用机制。
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A hypothesis concerning the mode of action of amiloride and of triamterene.关于氨氯吡咪和氨苯蝶啶作用方式的一种假说。
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Effects of ethacrynic acid and furosemide on urinary calcium, phosphate and magnesium.依他尼酸和呋塞米对尿钙、磷和镁的影响。
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Effects of chlorothiazide and amipramizide (MK 870) on the renal excretion of calcium, phosphate and magnesium.氯噻嗪和阿米普明（MK 870）对钙、磷和镁肾排泄的影响。
Metabolism. 1968 May;17(5):420-9. doi: 10.1016/0026-0495(68)90064-4.
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Pharmacological effects in animals and normal human subjects of the diuretic amiloride hydrochloride (MK-870).利尿药盐酸阿米洛利（MK - 870）对动物和正常人类受试者的药理作用。
Clin Pharmacol Ther. 1968 May-Jun;9(3):318-27. doi: 10.1002/cpt196893318.
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Effect of amiloride, ouabain, and furosemide on distal tubular function in the rat.氨氯吡咪、哇巴因和呋塞米对大鼠远曲小管功能的影响。
Am J Physiol. 1971 Aug;221(2):632-40. doi: 10.1152/ajplegacy.1971.221.2.632.
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Eur J Pharmacol. 1970 May;10(2):255-67. doi: 10.1016/0014-2999(70)90281-5.
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