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gamma-Radiolyses of DNA in oxygenated aqueous solution. Structure of an alkali-labile site.

作者信息

Dizdaroglu M, Schulte-Frohlinde D, von Sonntag C

出版信息

Z Naturforsch C Biosci. 1977 Nov-Dec;32(11-12):1021-2. doi: 10.1515/znc-1977-11-1226.

Abstract

Erythritol-1-d1 has been isolated from gamma-irradiated aqueous oxygenated solution of DNA after reductions with NaBD4, alkali and phosphatase treatment. It is concluded that this product stems from a D-erythrose 2,4-diphosphate unit in the DNA which is formed via a sequence of reactions following H-abstraction at C-2' by OH radicals.

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