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化学视角下的 DNA 的氧化与硝化修饰

Chemical Insights into Oxidative and Nitrative Modifications of DNA.

机构信息

Hospital Clínico Universitario, Avenida de Ramón y Cajal, 3, 47003 Valladolid, Spain.

Institute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. AstrofísicoFco. Sánchez, 3, 38206 La Laguna, Spain.

出版信息

Int J Mol Sci. 2023 Oct 16;24(20):15240. doi: 10.3390/ijms242015240.

DOI:10.3390/ijms242015240
PMID:37894920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10607741/
Abstract

This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and nitrating species, and it may play an important role in the pathophysiology of inflammation, cancer, and degenerative diseases. Infection and chronic inflammation have been recognized as important factors in carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. Cellular DNA is continuously exposed to a very high level of genotoxic stress caused by physical, chemical, and biological agents, with an estimated 10,000 modifications occurring every hour in the genetic material of each of our cells. This review highlights recent developments in the chemical biology and toxicology of 2'-deoxyribose oxidation products in DNA.

摘要

这篇综述主要关注由各种氧化、烷化和硝化物质引起的 DNA 损伤，这些损伤可能在炎症、癌症和退行性疾病的病理生理学中发挥重要作用。感染和慢性炎症已被认为是致癌的重要因素。在炎症条件下，活性氧（ROS）和活性氮（RNS）由炎症和上皮细胞产生，导致氧化和硝化 DNA 损伤的形成，如 8-氧代-7,8-二氢-2'-脱氧鸟苷（8-oxodG）和 8-硝基鸟嘌呤。细胞 DNA 不断暴露于由物理、化学和生物制剂引起的极高水平的遗传毒性应激下，我们每个细胞的遗传物质每小时估计会发生 10,000 次修饰。这篇综述强调了 DNA 中 2'-脱氧核糖氧化产物的化学生物学和毒理学的最新进展。

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Antioxidants (Basel). 2025 Jul 4;14(7):825. doi: 10.3390/antiox14070825.
7
Generation of cellular reactive oxygen and nitrogen species by exposure to ultraviolet radiation.通过暴露于紫外线辐射产生细胞活性氧和氮物种。
Biophys Rev. 2025 Mar 14;17(2):547-560. doi: 10.1007/s12551-025-01298-7. eCollection 2025 Apr.
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Effects of iron accumulation and its chelation on oxidative stress in intracortical implants.铁蓄积及其螯合对皮质内植入物氧化应激的影响。
Acta Biomater. 2025 Jun 15;200:703-723. doi: 10.1016/j.actbio.2025.05.026. Epub 2025 May 10.
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Transforming beef quality through healthy breeding: a strategy to reduce carcinogenic compounds and enhance human health: a review.通过健康养殖改善牛肉品质：减少致癌化合物并促进人类健康的策略：综述
Mamm Genome. 2025 May 9. doi: 10.1007/s00335-025-10129-9.
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A Proprietary Extract, Its Antioxidant Properties Using Multi-Radical Assays and Protection Against UVA-Induced Damages in a Reconstructed Human Skin Model.一种专利提取物，利用多自由基分析方法研究其抗氧化特性以及在重建人皮肤模型中对UVA诱导损伤的防护作用。
Antioxidants (Basel). 2025 Feb 28;14(3):301. doi: 10.3390/antiox14030301.
基于去氢枞酸 B 环稠合噻唑的噻唑烷酮衍生物的合成、抗肿瘤评价及计算研究。
Mol Divers. 2024 Apr;28(2):875-888. doi: 10.1007/s11030-023-10626-6. Epub 2023 Mar 2.
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Superoxide Anion Chemistry-Its Role at the Core of the Innate Immunity.超氧阴离子化学——其在固有免疫中的核心作用。
Int J Mol Sci. 2023 Jan 17;24(3):1841. doi: 10.3390/ijms24031841.
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Enantioselective Intramolecular α-Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine.手性选择性的苯甲胺衍生物的分子内 α-芳基化反应：左西替利嗪前体的合成。
Angew Chem Int Ed Engl. 2023 Mar 27;62(14):e202216758. doi: 10.1002/anie.202216758. Epub 2023 Feb 23.
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Elucidation of reactive oxygen species scavenging pathways of norbergenin utilizing DFT approaches.利用密度泛函理论方法阐明降冰片烯宁的活性氧清除途径。
R Soc Open Sci. 2022 Dec 21;9(12):221349. doi: 10.1098/rsos.221349. eCollection 2022 Dec.
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DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities.癌症治疗与耐药中的 DNA 损伤反应：挑战与机遇。
Int J Mol Sci. 2022 Nov 24;23(23):14672. doi: 10.3390/ijms232314672.
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Impact of Reactive Species on Amino Acids-Biological Relevance in Proteins and Induced Pathologies.活性物种对氨基酸的影响-蛋白质中的生物学相关性和诱导病理学。
Int J Mol Sci. 2022 Nov 14;23(22):14049. doi: 10.3390/ijms232214049.
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The Role of Reactive Species on Innate Immunity.活性物质在固有免疫中的作用。
Vaccines (Basel). 2022 Oct 17;10(10):1735. doi: 10.3390/vaccines10101735.
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Mechanisms of Action of the Antimicrobial Peptide Cecropin in the Killing of .抗菌肽天蚕素在杀灭……过程中的作用机制
Life (Basel). 2022 Oct 11;12(10):1581. doi: 10.3390/life12101581.