Institute of Pathology, Policlinico A. Gemelli, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Endoscopy. 2013;45(5):401-4. doi: 10.1055/s-0032-1326213. Epub 2013 Apr 24.
Pancreaticoduodenectomy is the standard care for invasive ampullary adenocarcinomas. However, endoscopic snare papillectomy (ESP) might play a curative role in very selected patients. We studied a series of 15 patients with T1 ampullary adenocarcinoma who were treated by ESP alone and followed up for a mean of 29.6 ± 21.9 months (range 8 - 81 months). ESP was curative for eight patients (57.1 %). No tumor-related death was observed in patients with a cancer infiltration depth of ≤ 4 mm. According to this preliminary experience, we suggest that this measurable variable threshold should be considered as a possible basis for future large-scale studies.
胰十二指肠切除术是治疗侵袭性壶腹腺癌的标准方法。然而，内镜下圈套乳头切除术（ESP）可能在非常特定的患者中发挥治疗作用。我们研究了一组 15 例 T1 壶腹腺癌患者，他们仅接受 ESP 治疗并平均随访 29.6 ± 21.9 个月（范围 8-81 个月）。ESP 对 8 例患者（57.1%）是治愈性的。浸润深度≤4mm 的患者未观察到肿瘤相关死亡。根据这初步经验，我们建议将此可测量的变量阈值作为未来大规模研究的可能基础。
