Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, PR China.
Langmuir. 2013 May 21;29(20):6013-7. doi: 10.1021/la400910g. Epub 2013 May 7.
The organization of peptides and proteins attracts much attention, due to the biofunctionalities of the self-assemblies. Herein, four dipeptides derived from alanine were synthesized. It was found that the handedness of their self-assemblies was controlled by the chirality of the alanines at the terminals. The organic self-assemblies were studied using circular dichroism, (1)H NMR, Fourier transform infrared, field-emission electron microscopy, transmission electron microscopy, and X-ray diffraction. The results indicated that the electrostatic interactions among the carboxylate groups and H-bondings among the amide groups at the terminals play important roles in the formation of the organic self-assemblies.
由于自组装体的生物功能，肽和蛋白质的组织引起了广泛关注。在此，合成了四个源自丙氨酸的二肽。结果发现，它们自组装体的手性由末端丙氨酸的手性控制。使用圆二色性、（1）H NMR、傅里叶变换红外、场发射电子显微镜、透射电子显微镜和 X 射线衍射研究了有机自组装体。结果表明，末端羧酸盐基团之间的静电相互作用和酰胺基团之间的氢键在有机自组装体的形成中起着重要作用。
