School of Veterinary Medicine and Biomedical Sciences and the Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA.
DNA Cell Biol. 2013 Jun;32(6):286-91. doi: 10.1089/dna.2013.2054. Epub 2013 Apr 25.
The processing bodies (PBs) are a form of cytoplasmic aggregates that house the cellular RNA decay machinery as well as many RNA-binding proteins and mRNAs. The PBs are constitutively present in eukaryotic cells and are involved in maintaining cellular homeostasis by regulating RNA metabolism, cell signaling, and survival. Virus infections result in modification of the PBs and their constituents. Many viruses induce compositionally altered PBs, while many others use specific components of the PBs for their replication. PB constituents are also known to restrict virus replication by a variety of mechanisms. Further, continuing studies in this rapidly emerging field of PB-virus interactions will undoubtedly provide important clues to the understanding of the role of PBs in cellular homeostasis as well as their role in virus infections and innate immune signaling.
处理体（PBs）是一种细胞质聚集体，其中包含细胞 RNA 降解机制以及许多 RNA 结合蛋白和 mRNAs。PBs 存在于真核细胞中，通过调节 RNA 代谢、细胞信号转导和存活来维持细胞内稳态。病毒感染会导致 PBs 及其成分发生改变。许多病毒诱导组成性改变的 PBs，而许多其他病毒则利用 PBs 的特定成分进行复制。PB 成分也通过多种机制限制病毒复制。此外，在这个迅速发展的 PB-病毒相互作用领域的持续研究无疑将为理解 PBs 在细胞内稳态中的作用以及它们在病毒感染和先天免疫信号中的作用提供重要线索。
