Clin Exp Dermatol. 2013 Oct;38(7):768-74. doi: 10.1111/ced.12049. Epub 2013 Mar 21.
Recent work using genome–wide association studies (GWAS) in Chinese Han and white populations have discovered several novel psoriasis susceptibility genes.
To examine whether the risk loci for psoriasis identified in previous GWAS in a white population are also associated with psoriasis in a Chinese Uygur population in Xinjiang.
Genotyping analysis of eight single-nucleotide polymorphisms (SNPs) associated with psoriasis was performed for 539 patients with psoriasis and 749 controls, all of Chinese Uygur descent, using a commercial assay.
Two SNPs had an association with psoriasis in this Chinese Uygur population: SNP rs495337 in the gene encoding for zinc finger protein 313 (P < 0.001; OR = 0.80) and SNP rs20541 of the gene encoding for interleukin-13 (P < 0.001; OR = 0.82). In subgroup analyses, the two SNPs were significantly associated (P < 0.05) with type I psoriasis, Rs495337 showed statistically difference between positive family history of psoriasis patients and controls whereas rs20541 might preferentially associated with negative family history psoriasis patients. Interestingly, using multifactor dimensionality reduction, a significant two-locus interaction was seen between rs495337 and rs20541, with a crossvalidation consistency of 4/5 and average balanced prediction (accuracy 55.5%, P < 0.001).
ZNF313 and IL-13 are associated with risk for psoriasis in a Chinese Uygur population, and there is an effect of interaction between the two genes on this risk.
最近利用全基因组关联研究（GWAS）在汉族和白种人群中发现了几个新的银屑病易感基因。
研究在中国新疆维吾尔族人群中，之前在白种人群中发现的银屑病 GWAS 风险基因是否也与银屑病相关。
采用商业试剂盒对 539 例银屑病患者和 749 例对照（均为维吾尔族）的 8 个与银屑病相关的单核苷酸多态性（SNP）进行基因分型分析。
在这个维吾尔族人群中，有 2 个 SNP 与银屑病相关：编码锌指蛋白 313 的基因中的 SNP rs495337（P<0.001；OR=0.80）和编码白细胞介素-13 的基因中的 SNP rs20541（P<0.001；OR=0.82）。在亚组分析中，这两个 SNP 与 1 型银屑病显著相关（P<0.05）。SNP rs495337 在有银屑病阳性家族史的患者和对照组之间存在统计学差异，而 rs20541 可能与无银屑病阳性家族史的患者优先相关。有趣的是，使用多因子降维分析，rs495337 和 rs20541 之间存在显著的两基因相互作用，交叉验证一致性为 4/5，平均平衡预测准确率为 55.5%（P<0.001）。
ZNF313 和 IL-13 与中国维吾尔族人群的银屑病风险相关，并且这两个基因之间存在相互作用的影响。
