银屑病的遗传易感性及相关基因与治疗选择的关系。
The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to Our Treatment Options.
机构信息
Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, NC 27104, USA.
The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Int J Mol Sci. 2023 Aug 1;24(15):12310. doi: 10.3390/ijms241512310.
Understanding the factors creating genetic susceptibility in psoriasis may provide a basis for improving targeted treatment strategies. In this review, we discuss the genes linked to the pathogenesis of psoriasis and their relationship to the available treatment options. To identify the relevant genetic markers and treatments, we searched PubMed, Google Scholar, MEDLINE, and Web of Science with keywords, including , , , and . The articles in English from database inception to 1/1/23 were included. Case reports and series were excluded. Gene variant forms commonly implicated in the pathogenesis of psoriasis include those encoding for interleukins, interferons, and other mediators involved in inflammatory pathways, such as JAK/STAT, and NF-κB. Several of the treatments for psoriasis (for example IL23 and TYK2 inhibitors) target the products of genes linked to psoriasis. Multiple genes are linked to the pathogenesis of psoriasis. This understanding may provide an avenue for the development of new psoriasis treatment strategies and for more effective, safer treatment outcomes.
了解导致银屑病遗传易感性的因素可能为改善靶向治疗策略提供基础。在这篇综述中，我们讨论了与银屑病发病机制相关的基因及其与现有治疗选择的关系。为了确定相关的遗传标志物和治疗方法，我们使用关键词在 PubMed、Google Scholar、MEDLINE 和 Web of Science 上进行了搜索，包括 、 、 、 。纳入了从数据库建立到 2023 年 1 月 1 日的英文文章。排除了病例报告和系列。在银屑病发病机制中常见的基因变异形式包括编码白细胞介素、干扰素和其他参与炎症途径的介质的基因，如 JAK/STAT 和 NF-κB。几种银屑病治疗方法（例如 IL23 和 TYK2 抑制剂）针对与银屑病相关的基因产物。多个基因与银屑病的发病机制有关。这种认识可能为开发新的银屑病治疗策略以及更有效、更安全的治疗结果提供途径。
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