Ralph H. Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29401, USA.
Am J Addict. 2013 May-Jun;22(3):261-5. doi: 10.1111/j.1521-0391.2012.12008.x.
Comorbid substance use disorders and mood and anxiety disorders are associated with more severe psychiatric symptoms, social and occupational impairment, and economic burden. To date, the majority of research has focused on comorbidity in illicit drug users, rather than prescription drug users. To address this gap in the literature, the present cross-sectional study investigated the clinical profiles of individuals with prescription opioid dependence with or without comorbid mood and anxiety disorders.
Ninety individuals with prescription opioid use were recruited to participate in the study procedures. All participants completed a structured clinical interview and series of self-report measures.
Of the 85 individuals with prescription opioid dependence, 47.1% (n = 40) were diagnosed with a comorbid mood or anxiety disorder. The findings showed that individuals with prescription opioid dependence and comorbid mood and anxiety disorders demonstrated significantly more severe alcohol use, psychiatric symptoms, and sleep impairment than individuals without comorbidity.
The findings highlight the frequency and severity of co-occurring mood and anxiety disorders in individuals with prescription opioid dependence and suggest that integrated interventions are needed to address these growing problems.
合并物质使用障碍、心境和焦虑障碍与更严重的精神症状、社会和职业功能损害以及经济负担相关。迄今为止，大多数研究都集中在非法药物使用者的共病上，而不是在处方药物使用者中。为了填补这一文献空白，本横断面研究调查了有或没有合并心境和焦虑障碍的阿片类药物处方依赖者的临床特征。
招募了 90 名阿片类药物处方使用者参与研究程序。所有参与者都完成了结构化临床访谈和一系列自我报告评估。
在 85 名有阿片类药物处方依赖的个体中，47.1%（n=40）被诊断为合并心境或焦虑障碍。研究结果表明，与无共病者相比，有阿片类药物处方依赖和合并心境和焦虑障碍的个体表现出更严重的酒精使用、精神症状和睡眠障碍。
这些发现强调了在有阿片类药物处方依赖的个体中合并心境和焦虑障碍的频率和严重程度，并提示需要采取综合干预措施来解决这些日益严重的问题。
