Silva Marcelina Jasmine, Coffee Zhanette, Yu Chong Ho Alex, Hu Joshua
The Focus on Opioid Transitions (FOOT Steps) Program, IPM Medical Group, Walnut Creek, CA 94598, USA.
College of Nursing, University of Arizona, Tucson, AZ 85721, USA.
J Clin Med. 2023 Feb 8;12(4):1354. doi: 10.3390/jcm12041354.
Improved understanding of psychological features associated with full mu agonist long-term opioid therapy (LTOT) cessation may offer advantages for clinicians. This preliminary study presents changes in psychological outcomes in patients with chronic, non-cancer pain (CNCP) after LTOT cessation via a 10-week multidisciplinary program which included treatment with buprenorphine. Paired -tests pre- and post-LTOT cessation were compared in this retrospective cohort review of data from electronic medical records of 98 patients who successfully ceased LTOT between the dates of October 2017 to December 2019. Indicators of quality of life, depression, catastrophizing, and fear avoidance, as measured by the 36-Item Short Form Survey, the Patient Health Questionnaire-9-Item Scale, the Pain Catastrophizing Scale, and the Fear Avoidance Belief Questionnaires revealed significant improvement. Scores did not significantly improve for daytime sleepiness, generalized anxiety, and kinesiophobia, as measured by the Epworth Sleepiness Scale, the Generalized Anxiety Disorder 7-Item Scale, and the Tampa Scale of Kinesiophobia. The results suggest that successful LTOT cessation may be interconnected with improvements in specific psychological states.
更好地理解与完全μ激动剂长期阿片类药物治疗（LTOT）戒断相关的心理特征，可能会给临床医生带来好处。这项初步研究展示了慢性非癌性疼痛（CNCP）患者在通过为期10周的多学科项目（包括丁丙诺啡治疗）戒断LTOT后心理结果的变化。在这项回顾性队列研究中，对98例在2017年10月至2019年12月期间成功戒断LTOT的患者的电子病历数据进行了配对t检验，比较了LTOT戒断前后的情况。通过36项简短调查问卷、患者健康问卷9项量表、疼痛灾难化量表和恐惧回避信念问卷测量的生活质量、抑郁、灾难化和恐惧回避指标显示有显著改善。通过爱泼华嗜睡量表、广泛性焦虑障碍7项量表和坦帕运动恐惧量表测量的白天嗜睡、广泛性焦虑和运动恐惧得分没有显著改善。结果表明，成功戒断LTOT可能与特定心理状态的改善相互关联。
