Lissner L, Andres R, Muller D C, Shimokata H
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-3246.
Int J Obes. 1990 Apr;14(4):373-83.
The health implications of body weight fluctuation were examined using data from 846 men with a mean age of 56.4 years, enrolled in the Baltimore Longitudinal Study of Aging. Body weight fluctuation was studied in relation to three general categories of health-related outcome: (i) basal metabolic rate, (ii) risk factors for coronary heart disease (CHD), and (iii) rates of CHD, cancer mortality, and all-cause mortality. Weight fluctuation was defined as intraindividual variability in body weight about a time-dependent regression slope. Outcomes (i) and (ii) were described in terms of a subject's rate of change during the same time period. All analyses were adjusted for three covariates: age, level of obesity and linear trend in body weight over time. (i) Body weight variability is positively associated with changes in metabolic rate expressed either per surface area or per lean body mass (i.e. less decrease over time among the most weight-variable men). (ii) Body weight variability is associated with greater decreases in glucose tolerance and with greater increases in the ratio of subscapular to triceps skinfolds, but not with changes in systolic blood pressure, waist-hip ratio, serum cholesterol or triglyceride levels. (iii) Body weight variability is not predictive of subsequent CHD, cancer, or all-cause mortality. These results do not confirm previous findings regarding weight fluctuation and 'hard' endpoints but do raise the possibility that weight cycling might modify eventual cardiovascular risk via adipose redistribution or glucose tolerance impairment.
利用参加巴尔的摩纵向衰老研究的846名平均年龄为56.4岁男性的数据，研究了体重波动对健康的影响。研究了体重波动与三类一般健康相关结果的关系：（i）基础代谢率，（ii）冠心病（CHD）危险因素，以及（iii）冠心病发病率、癌症死亡率和全因死亡率。体重波动定义为体重围绕时间依赖性回归斜率的个体内变异性。结果（i）和（ii）根据同一时间段内受试者的变化率进行描述。所有分析均针对三个协变量进行了调整：年龄、肥胖程度和体重随时间的线性趋势。（i）体重变异性与按体表面积或瘦体重计算的代谢率变化呈正相关（即体重变化最大的男性随时间的下降幅度较小）。（ii）体重变异性与葡萄糖耐量的更大下降以及肩胛下与肱三头肌皮褶厚度比值的更大增加有关，但与收缩压、腰臀比、血清胆固醇或甘油三酯水平的变化无关。（iii）体重变异性不能预测随后的冠心病、癌症或全因死亡率。这些结果并未证实先前关于体重波动和“硬”终点的研究结果，但确实增加了体重循环可能通过脂肪重新分布或葡萄糖耐量受损来改变最终心血管风险的可能性。
