Department of Medical College, Jinhua Polytechnic, JinHua, China.
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Int J Public Health. 2022 Apr 14;67:1604654. doi: 10.3389/ijph.2022.1604654. eCollection 2022.
To examine the association between smoking cessation and risk of type 2 diabetes with emphasis on post-cessation weight gain. In total, 8,951 participants from the China Health and Retirement Longitudinal Study at the baseline (2011) were included. Diabetes incidence was accessed at the third survey (2015). Current smokers were treated as the reference and odds ratios (OR) of type 2 diabetes for never smokers, recent, and long-term quitters were computed using multivariable logistic regression. Stratified analysis was further conducted by weight gain after smoking cessation. There were 712 cases of type 2 diabetes identified. Compared with current smokers, the fully multivariable-adjusted ORs were 1.55 (1.02, 2.36) for recent quitters, 0.88 (0.61, 1.28) for long-term quitters, and 0.75 (0.59, 0.95) for never smokers. Stratified analysis showed recent quitters with weight gain of ≥2.0 kg had a significantly higher odds of type 2 diabetes [2.25 (1.02, 4.95)]. The present study of the Chinese population suggested recent quitters with weight gain of ≥2.0 kg, compared with current smokers, had a significantly increased odds of type 2 diabetes.
探讨戒烟与 2 型糖尿病风险的相关性，重点关注戒烟后的体重增加。
本研究共纳入了中国健康与养老追踪调查（CHARLS）中的 8951 名基线（2011 年）时的参与者。在第三次调查（2015 年）时评估糖尿病的发病情况。将当前吸烟者作为参照，使用多变量逻辑回归计算从不吸烟者、近期戒烟者和长期戒烟者发生 2 型糖尿病的比值比（OR）。进一步进行了按戒烟后体重增加分层的分析。
共确诊了 712 例 2 型糖尿病。与当前吸烟者相比，近期戒烟者的完全多变量校正 OR 为 1.55（1.02，2.36），长期戒烟者为 0.88（0.61，1.28），从不吸烟者为 0.75（0.59，0.95）。分层分析显示，体重增加≥2.0kg 的近期戒烟者发生 2 型糖尿病的可能性显著更高[2.25（1.02，4.95）]。
本项中国人群研究表明，与当前吸烟者相比，体重增加≥2.0kg 的近期戒烟者发生 2 型糖尿病的风险显著增加。
