O'Brien A A, Moore D P, Keogh J A
Department of Clinical Medicine, Meath Hospital, Dublin.
Ir J Med Sci. 1990 Mar;159(3):71-3. doi: 10.1007/BF02946671.
When the aluminium content of the water supply to our Haemodialysis Unit rose from less than 0.5 mumol/l to 6 mumol/l over a two month period, we carried out bone biopsies and desferrioxamine infusion tests on twelve (12) patients who had been on haemodialysis for less than one year (mean 8 months) and had normal serum aluminium levels. The patients had no bone symptoms. Eight patients had positive aluminium bone stains. The aluminium osteomalacia group (n = 8) had a mean PTH of 1.4 ng/ml s.e. 0.3 whereas the non-ALO group had a mean PTH of 2.9 ng/ml s.e. 0.7. The difference in mean PTH is significant (p less than 0.05). There was no evidence of encephalopathy, fractures or microcytic anaemia in the ALO positive group. The aluminium contamination of the water supply occurred because of a change in the reservoir purification system from sand-filtration to alum.
在两个月的时间里，我们血液透析单元的供水铝含量从低于0.5微摩尔/升升至6微摩尔/升，于是我们对12名血液透析时间不到一年（平均8个月）且血清铝水平正常的患者进行了骨活检和去铁胺输注试验。这些患者没有骨骼症状。8名患者的铝骨染色呈阳性。铝骨软化症组（n = 8）的甲状旁腺激素（PTH）平均水平为1.4纳克/毫升，标准误为0.3，而非铝骨软化症组的PTH平均水平为2.9纳克/毫升，标准误为0.7。PTH平均水平的差异具有统计学意义（p小于0.05）。铝骨软化症阳性组没有出现脑病、骨折或小细胞性贫血的迹象。供水受到铝污染是因为蓄水池净化系统从砂滤改为了明矾。
