Charhon S A, Chavassieux P M, Meunier P J, Accominotti M
Br Med J (Clin Res Ed). 1985 Jun 1;290(6482):1613-4. doi: 10.1136/bmj.290.6482.1613.
Serum aluminium concentrations and biopsy specimens of bone were examined in 56 patients with end stage chronic renal failure receiving maintenance haemodialysis. Deposits of aluminium in bone specimens were often associated with low bone formation with or without osteomalacia. Serum aluminium concentrations of greater than 3.7 mumol/l (10 micrograms/100 ml) indicated a high probability of deposits of aluminium in bone specimens, although high serum concentrations did not predict the type of renal bone disease. Biopsy of the bone is the best method of detecting aluminium intoxication of bone. A serum aluminium concentration of 3.7 mumol/l should be the threshold beyond which bone biopsy should be performed to confirm an overload of aluminium and identify histological bone changes induced by aluminium.
对56例接受维持性血液透析的终末期慢性肾衰竭患者的血清铝浓度和骨活检标本进行了检查。骨标本中的铝沉积常与低骨形成有关，无论有无骨软化症。血清铝浓度大于3.7μmol/L（10μg/100ml）表明骨标本中铝沉积的可能性很高，尽管高血清浓度并不能预测肾性骨病的类型。骨活检是检测骨铝中毒的最佳方法。血清铝浓度3.7μmol/L应作为阈值，超过该阈值应进行骨活检以确认铝过载并识别铝引起的组织学骨变化。
