CNRS, LCPM, FRE3564, Nancy F-54001, France.
Carbohydr Polym. 2013 Jun 5;95(1):360-5. doi: 10.1016/j.carbpol.2013.03.010. Epub 2013 Mar 13.
Hydrophobically modified dextrans were prepared by reacting native polysaccharide with 1,2-epoxydodecane in dimethylsulfoxide. Epoxide oligomerization was shown to occur as a secondary reaction when hydroxide ions were used as base catalysts. By adjusting the amount of epoxide in the feed, dextran derivatives with degrees of substitution (DS) between 0% and 164% were obtained. Polymers with DS above 100% were readily soluble in organic solvents like tetrahydrofuran, dioxane and water-saturated chloroform and dichloromethane. Their solution properties in organic solvent were characterized by capillary viscometry. Water-soluble derivatives were compared to other amphiphilic dextrans obtained using a heterogeneous modification in aqueous medium. The effect of modification conditions on substitution pattern was evidenced.
疏水改性葡聚糖是通过在二甲基亚砜中使天然多糖与 1,2-环氧十二烷反应制备的。当使用氢氧化物离子作为碱催化剂时，显示出环氧化物低聚物化作为次级反应发生。通过调整进料中环氧化物的量，获得了取代度（DS）在 0%至 164%之间的葡聚糖衍生物。DS 高于 100%的聚合物在有机溶剂如四氢呋喃、二恶烷和水饱和的氯仿和二氯甲烷中容易溶解。它们在有机溶剂中的溶液性质通过毛细管黏度计进行了表征。水溶性衍生物与在水介质中使用非均相改性获得的其他两亲性葡聚糖进行了比较。改性条件对取代模式的影响得到了证实。
