苏丹喀土穆的产时发热与脑瘫
Intra-partum fever and cerebral palsy in Khartoum, Sudan.
作者信息
Abdullahi Hala, Satti Mohamed, Rayis Duria A, Imam Abdulmutalab M, Adam Ishag
机构信息
Department of Obstetrics and Gynecology, University of Khartoum, Khartoum, Sudan.
出版信息
BMC Res Notes. 2013 Apr 24;6:163. doi: 10.1186/1756-0500-6-163.
BACKGROUND
Cerebral palsy (CP) is a major cause of childhood disability. There are various maternal and neonatal predictors associated with the development of CP, and they are variable across different populations. This case-control study was designed to investigate maternal and neonatal predictors of CP at Khartoum pediatric neurology clinics. Data (maternal sociodemographic characteristics and neonatal expected predictors) were collected from mothers of children with CP and healthy controls using questionnaires.
RESULTS
One hundred and eleven cases of CP and 222 controls were included. Spastic CP was the most common type (69.4%). In logistic regression, maternal age, parity, birth weight, and sex were not associated with CP. However, maternal fever (OR = 8.4, CI = 2.3-30.5; P = 0.001), previous neonatal death (OR = 5.4, CI = 1.8-16.2; P = 0.003), and poor sucking (OR = 30.5, CI = 10.0-93.1; P < 0.001) were predictors of CP.
CONCLUSIONS
Fever during labor is a significant risk factor for developing CP in children. Further efforts are required for labor management to prevent CP in this setting.
背景
脑瘫（CP）是儿童残疾的主要原因。有多种与脑瘫发生相关的母体和新生儿预测因素，且在不同人群中有所不同。本病例对照研究旨在调查喀土穆儿科神经科诊所中脑瘫的母体和新生儿预测因素。使用问卷从脑瘫患儿母亲和健康对照者的母亲那里收集数据（母体社会人口学特征和新生儿预期预测因素）。
结果
纳入111例脑瘫病例和222例对照。痉挛型脑瘫是最常见的类型（69.4%）。在逻辑回归分析中，母亲年龄、产次、出生体重和性别与脑瘫无关。然而，母亲发热（比值比[OR]=8.4，可信区间[CI]=2.3 - 30.5；P = 0.001）、既往新生儿死亡（OR = 5.4，CI = 1.8 - 16.2；P = 0.003）以及吸吮无力（OR = 30.5，CI = 10.0 - 93.1；P < 0.001）是脑瘫的预测因素。
结论
分娩期间发热是儿童发生脑瘫的一个重要危险因素。在这种情况下，需要进一步努力进行分娩管理以预防脑瘫。
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