State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
Neuroimage. 2014 Apr 1;89:226-34. doi: 10.1016/j.neuroimage.2013.04.043. Epub 2013 Apr 22.
The seven-factor biopsychosocial model of personality distinguished four biologically based temperaments and three psychosocially based characters. Previous studies have suggested that the four temperaments-novelty seeking (NS), reward dependence (RD), harm avoidance (HA), and persistence (P)-have their respective neurobiological correlates, especially in the striatum-connected subcortical and cortical networks. However, few studies have investigated their neurobiological basis in the form of fiber connectivity between brain regions. This study correlated temperaments with fiber connectivity between the striatum and subcortical and cortical hub regions in a sample of 50 Chinese adult males. Generally consistent with our hypotheses, results showed that: (1) NS was positively correlated with fiber connectivity from the medial and lateral orbitofrontal cortex (mOFC, lOFC) and amygdala to the striatum; (2) RD was positively correlated with fiber connectivity from the mOFC, posterior cingulate cortex/retrosplenial cortex (PCC), hippocampus, and amygdala to the striatum; (3) HA was positively linked to fiber connectivity from the dorsolateral prefrontal cortex (dlPFC) and PCC to the striatum; and (4) P was positively linked to fiber connectivity from the mOFC to the striatum. These results extended the research on the neurobiological basis of temperaments by identifying their anatomical fiber connectivity correlates within the subcortical-cortical neural networks.
七因素生物心理社会人格模型区分了四种基于生物学的气质和三种基于心理社会的性格。先前的研究表明，四种气质——寻求新奇（NS）、奖励依赖（RD）、回避伤害（HA）和坚持（P）——都有各自的神经生物学相关性，尤其是在与纹状体相连的皮质下和皮质网络中。然而，很少有研究以大脑区域之间的纤维连接的形式来探究它们的神经生物学基础。本研究在 50 名中国成年男性样本中，将人格与纹状体与皮质下和皮质枢纽区域之间的纤维连接相关联。结果与我们的假设基本一致，表明：（1）NS 与内侧和外侧眶额皮层（mOFC，lOFC）和杏仁核到纹状体的纤维连接呈正相关；（2）RD 与 mOFC、后扣带回/后扣带皮层（PCC）、海马体和杏仁核到纹状体的纤维连接呈正相关；（3）HA 与背外侧前额叶皮层（dlPFC）和 PCC 到纹状体的纤维连接呈正相关；（4）P 与 mOFC 到纹状体的纤维连接呈正相关。这些结果通过确定皮质下-皮质神经网络内的气质的解剖学纤维连接相关性，扩展了对气质神经生物学基础的研究。
