RNA Therapeutics Institute, Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Curr Biol. 2013 Apr 22;23(8):R318-20. doi: 10.1016/j.cub.2013.03.033.
Several recent studies demonstrate that piRNAs guide Piwi protein to repress transposon transcription in fly ovaries, much as fission yeast use siRNAs to silence repeat sequences. Still mysterious though is how Piwi targets euchromatic transposons for silencing, but not the specialized heterochromatic loci that produce piRNA precursors.
几项最近的研究表明，piRNAs 指导 Piwi 蛋白抑制果蝇卵巢中转座子的转录，就像裂殖酵母利用 siRNAs 沉默重复序列一样。然而，Piwi 如何靶向常染色质转座子进行沉默，而不是专门产生 piRNA 前体的异染色质位点，这仍然是一个谜。
