Division of Gastroenterology, Federal University of Santa Catarina, Brazil.
Ann Hepatol. 2013 May-Jun;12(3):456-63.
IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem to correlate with hepatic dysfunction intensity.
To investigate the significance of IGF-I and IGFBP-3 in patients with decompensated liver disease.
Cross-sectional study that included cirrhotic patients admitted to hospital due to complications of the disease, in whom IGF-I and IGFBP-3 serum levels were measured by chemiluminescence.
Seventy-four subjects with a mean age of 53.1 ± 11.6 years were included in the study, 73% were males. IGF-I levels were positively correlated with IGFBP-3 and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR and aPTT ratio. IGFBP-3 levels were positively correlated with IGF-I and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR, total bilirubin and aPTT ratio. Significantly lower scores of IGF-I and IGFBP-3 were observed in patients with higher MELD values and higher Child-Pugh classes (P < 0.05).
In cirrhotic patients admitted to hospital due to complications of the disease, IGF-I and IGFBP-3 serum levels were associated with variables related to liver dysfunction and to more advanced liver disease. The levels of these markers seem to undergo little influence from other clinical and laboratory variables, therefore mainly reflecting hepatic functional status.
IGF-I 和 IGFBP-3 是 IGF 系统的一部分，由于它们主要在肝脏中合成，因此它们似乎与肝功能损伤的严重程度相关。
研究 IGF-I 和 IGFBP-3 在失代偿性肝病患者中的意义。
这是一项横断面研究，纳入了因疾病并发症而住院的肝硬化患者，通过化学发光法测量其血清 IGF-I 和 IGFBP-3 水平。
本研究共纳入 74 例患者，平均年龄为 53.1 ± 11.6 岁，男性占 73%。IGF-I 水平与 IGFBP-3 和白蛋白呈正相关，与 Child-Pugh、MELD、肌酐、INR 和 aPTT 比值呈负相关。IGFBP-3 水平与 IGF-I 和白蛋白呈正相关，与 Child-Pugh、MELD、肌酐、INR、总胆红素和 aPTT 比值呈负相关。MELD 值较高和 Child-Pugh 分级较高的患者 IGF-I 和 IGFBP-3 的评分明显较低（P < 0.05）。
在因疾病并发症而住院的肝硬化患者中，血清 IGF-I 和 IGFBP-3 水平与肝功能损伤的相关变量以及更严重的肝病相关。这些标志物的水平似乎很少受到其他临床和实验室变量的影响，因此主要反映了肝脏的功能状态。
