高血压发生的地方。
Where hypertension happens.
机构信息
Laboratory of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal, Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.
出版信息
J Clin Invest. 2013 May;123(5):1934-6. doi: 10.1172/JCI69296. Epub 2013 Apr 24.
Abstract
Essential hypertension, which accounts for 90%-95% of all cases of hypertension seen in the clinic, is also referred to as idiopathic hypertension, because we simply don't understand the cause(s). Although many theories have been advanced, in the current issue of the JCI, Gonzalez-Villalobos et al. present further evidence implicating the intrarenal renin-angiotensin system and take us one step further by proposing a mechanism underlying this pathology.
摘要
原发性高血压占临床所见高血压病例的 90%-95%，也称为特发性高血压，因为我们根本不清楚其病因。虽然已经提出了许多理论，但在本期 JCI 中，Gonzalez-Villalobos 等人提出了进一步的证据，表明肾内肾素-血管紧张素系统与此相关，并通过提出该病理的一种机制，让我们更进一步。
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2
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Hypertension. 2013 Apr;61(4):806-11. doi: 10.1161/HYPERTENSIONAHA.111.00474. Epub 2013 Feb 4.
3
Renal denervation: ultima ratio or standard in treatment-resistant hypertension.肾去神经术：难治性高血压的终极手段还是标准疗法？
Hypertension. 2012 Sep;60(3):596-606. doi: 10.1161/HYPERTENSIONAHA.112.195263. Epub 2012 Jul 30.
4
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J Am Soc Nephrol. 2012 Jul;23(7):1181-9. doi: 10.1681/ASN.2011121159. Epub 2012 Apr 19.
5
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.常染色体隐性遗传性肾小管发育不良中肾素-血管紧张素系统基因突变谱。
Hum Mutat. 2012 Feb;33(2):316-26. doi: 10.1002/humu.21661. Epub 2011 Dec 22.
6
The role of the brain renin-angiotensin system in hypertension: implications for new treatment.脑肾素-血管紧张素系统在高血压中的作用：对新治疗方法的启示。
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