Diabetes Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California, USA.
J Clin Invest. 2013 May;123(5):1936-8. doi: 10.1172/JCI69297. Epub 2013 Apr 24.
Evidence that the pool of insulin-producing β cells in the pancreas is reduced in both major forms of diabetes mellitus has led to efforts to understand β cell turnover in the adult pancreas. Unfortunately, previous studies have reached opposing conclusions regarding the source of new β cells during regeneration in the adult pancreas. In this issue of the JCI, Xiao et al. use a novel mouse model for detecting new β cells derived from non-β cells to demonstrate the absence of β cell neogenesis from non-β cells during normal postnatal growth and in models of β cell regeneration. This work adds to mounting evidence that in most physiological and pathological conditions, β cell neogenesis may not make large contributions to the postnatal β cell pool - at least not in rodents.
证据表明，在两种主要类型的糖尿病中，胰腺中产生胰岛素的β细胞数量都减少了，这促使人们努力了解成年胰腺中β细胞的更新情况。不幸的是，之前的研究对于成年胰腺再生过程中新生β细胞的来源得出了相反的结论。在本期 JCI 中，Xiao 等人利用一种新的小鼠模型来检测源自非β细胞的新β细胞，从而证明在正常的出生后生长和β细胞再生模型中，β细胞不会从非β细胞中发生新生。这项工作进一步证明，在大多数生理和病理条件下，β细胞新生可能不会对出生后β细胞池做出很大的贡献——至少在啮齿动物中不是这样。
