Department of Neonatology, Rotunda Hospital, Dublin, Ireland.
J Perinatol. 2013 Sep;33(9):681-6. doi: 10.1038/jp.2013.39. Epub 2013 Apr 25.
To investigate myocardial velocities in anemic very low-birth weight (VLBW) preterm infants, pre and post red blood cells transfusion using tissue Doppler imaging echocardiography.
Forty-eight VLBW preterm infants34 weeks and>2 weeks old were prospectively divided: Transfused symptomatic infants (Hematocrit (Hct)<0.30 (n=32)) and non transfused asymptomatic controls (control 1, Hct >0.30 (n=9) and control 2, Hct <0.30 (n=7)). Echocardiography was performed before and 3-5 days after transfusion in the transfused, and the controls were studied at similar intervals. Non parametric tests were used for statistical analysis.
Left ventricular (LV) systolic velocity increased (transfused (4.6±0.70 vs 6.0±0.65, P<0.01)) as did LV diastolic velocities (P<0.01) without significant difference over time in each control. The percentage change in LV velocity following transfusion correlated negatively (ρ=0.36) with pre transfusion Hct.
There is a significant increase in myocardial performance following transfusion, which is related to the severity of the anemia.
使用组织多普勒成像超声心动图研究贫血极低出生体重（VLBW）早产儿输血前后的心肌速度。
48 名 VLBW 早产儿（胎龄<34 周且>2 周）前瞻性分为：输血症状性婴儿（Hct<0.30（n=32））和非输血无症状对照组（对照组 1，Hct>0.30（n=9）和对照组 2，Hct<0.30（n=7））。在输血前和输血后 3-5 天对输血组进行超声心动图检查，对照组在相似的时间间隔进行研究。非参数检验用于统计分析。
左心室（LV）收缩速度增加（输血组（4.6±0.70 对 6.0±0.65，P<0.01）），LV 舒张速度也增加（P<0.01），但每个对照组的速度随时间变化无显著差异。输血后 LV 速度的百分比变化与输血前 Hct 呈负相关（ρ=0.36）。
输血后心肌功能显著增加，与贫血的严重程度有关。
