Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA.
Laryngoscope. 2013 May;123(5):1207-9. doi: 10.1002/lary.23938.
Delayed lower cranial neuropathy is a rare complication following primary radiotherapy for head and neck cancer, and has been most associated with nasopharyngeal carcinoma with minimal data regarding this outcome in the treatment of the oropharynx. No reports, to the authors' knowledge, have described this complication following intensity modulated radiation therapy (IMRT) for oropharyngeal primaries. Once encountered, this adverse outcome can have serious impacts on speech and swallowing. We present here our institution's experience with delayed cranial neuropathies following primary radiation therapy for oropharyngeal squamous cell carcinoma, as well as document the only reported case following IMRT.
延迟性颅神经病变是头颈部癌症初次放疗后的罕见并发症，与鼻咽癌的关系最为密切，但关于口咽癌治疗结果的相关数据很少。据作者所知，尚无调强放疗（IMRT）治疗口咽原发性肿瘤后出现这种并发症的报道。一旦发生，这种不良后果会严重影响言语和吞咽功能。在此，我们介绍本机构在口咽鳞状细胞癌初次放疗后出现颅神经病变的经验，并报道首例 IMRT 后出现的病例。
