Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Research Hospital, Kızılay sok. No. 2, 06100, Sıhhıye, Ankara, Turkey.
Wien Klin Wochenschr. 2013 May;125(9-10):279-82. doi: 10.1007/s00508-013-0363-x. Epub 2013 Apr 26.
The aim of this study was to demonstrate that the presence of atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA) in indeterminate colitis (IC) patients and the potential role of pANCA for predicting the patients either with ulcerative colitis (UC) or Crohn's disease (CD) for UC and CD.
Outpatients and inpatients from the hospital were retrospectively enrolled between April 2008 and December 2010. A total of 25 IC patients enrolled in the present study. Subsequently, 25 randomly selected serum samples were tested for pANCA in our laboratory. Determination of pANCA was performed by enzyme linked immunosorbent assay.
Minimum follow-up was 12 months. The mean duration of disease was 20.52 months. The diagnosis was changed to UC in 13, to CD in 5 patients. The remaining 7 patients are still classified with IC, with mean disease duration of 21.29 months. Duration of disease differs statistically when comparing pANCA positive versus pANCA negative. A positive correlation was found between IC and disease location in our study.
Patients with an initial diagnosis of IC who have positive serology are given a definitive diagnosis of UC or CD, respectively, more often than patients with negative serology.
本研究旨在证明不典型核周型抗中性粒细胞胞浆抗体（pANCA）在不确定结肠炎（IC）患者中的存在，以及 pANCA 预测患者为溃疡性结肠炎（UC）或克罗恩病（CD）的潜在作用。
2008 年 4 月至 2010 年 12 月期间，我们回顾性地招募了来自医院的门诊和住院患者。本研究共纳入 25 例 IC 患者。随后，在我们的实验室中检测了 25 例随机选择的血清样本中的 pANCA。通过酶联免疫吸附试验测定 pANCA。
最小随访时间为 12 个月。疾病的平均持续时间为 20.52 个月。13 例诊断为 UC，5 例诊断为 CD。其余 7 例仍归类为 IC，平均疾病持续时间为 21.29 个月。比较 pANCA 阳性与 pANCA 阴性时，疾病持续时间存在统计学差异。在我们的研究中，发现 IC 与疾病部位之间存在正相关。
在初始诊断为 IC 的患者中，阳性血清学患者比阴性血清学患者更常被明确诊断为 UC 或 CD。
