Department of Orthopaedic Surgery, Korea University Guro Hospital, 97 Gurodong-gil, Guro-gu, Seoul 152-703, Korea.
Arch Orthop Trauma Surg. 2013 Jul;133(7):889-92. doi: 10.1007/s00402-013-1760-3. Epub 2013 Apr 26.
Recent reports on atypical femoral fracture have raised concerns about the long-term use of bisphosphonate. More recent case series focus specifically on the subtrochanteric fractures. But, there is relatively rarity and unawareness of atypical fracture in upper extremity. We report forearm fracture in two women receiving long-term bisphosphonate therapy. First woman presented with pain in the forearm and both thighs and radiographs showed incomplete fractures in a proximal ulnar shaft and bilateral femoral shaft. The other woman had a fracture in the radial shaft. This report suggests atypical fractures associated long-term use of bisphosphonate could occur in bones other than femur. More study is required to identify the magnitude of clinical features of this emerging concern.
最近关于非典型股骨骨折的报告引起了人们对长期使用双膦酸盐的担忧。最近的病例系列专门关注转子下骨折。但是，上肢的非典型骨折相对罕见且不为人知。我们报告了两名接受长期双膦酸盐治疗的女性前臂骨折。第一例女性出现前臂和大腿疼痛，X 线片显示尺骨干近端和双侧股骨干不完全骨折。另一名女性桡骨干骨折。本报告提示长期使用双膦酸盐可导致除股骨以外的骨骼发生非典型骨折。需要进一步研究以确定这一新兴问题的临床特征的严重程度。
