一种新型自发白化C57BL/6N小鼠品系的基因组分析。
Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.
作者信息
Ryder Edward, Wong Kim, Gleeson Diane, Keane Thomas M, Sethi Debarati, Vyas Sapna, Wardle-Jones Hannah, Bussell James N, Houghton Richard, Salisbury Jennifer, Harvey Nina, Adams David J, Ramirez-Solis Ramiro
机构信息
The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom.
出版信息
Genesis. 2013 Jul;51(7):523-8. doi: 10.1002/dvg.22398. Epub 2013 May 25.
We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background.
我们报告了一种白化C57BL/6N小鼠品系，其酪氨酸酶基因存在自发突变（C57BL/6N-Tyr(cWTSI)）。对奠基小鼠进行的深度全基因组测序显示，与C57BL/6NJ和C57BL/6N（Taconic）的差异非常小。这种同基因品系对于使用欧盟COMM/KOMP靶向C57BL/6N胚胎干细胞资源的国际小鼠表型分析联盟（IMPC）以及其他希望在明确的C57BL/6N背景下开展研究的人员将具有很大的实用价值。
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