Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, Australia.
Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3560-8. doi: 10.1167/iovs.12-10465.
The relationship between clinical severity of age-related macular degeneration (AMD) and macular function has not been well established. In this study, we investigated the correlation between clinical severity and functional deficits as detected by static and flicker perimetry.
This cross-sectional study consisted of 279 AMD subjects and 24 control participants. AMD subjects were allocated into 1 of 10 AMD severity groups depending on the status of the designated study eye and the fellow eye, as assessed by color fundus photographs. Visual acuity, and static and flicker perimetry were tested on one eye during the same session. The geometric means, SDs, and percentage of abnormal eyes of static and flicker sensitivity of each AMD severity group were determined and compared.
The pattern of change in sensitivity and percentage of abnormal eyes for static perimetry across all AMD severity groups were similar to flicker perimetry. Eyes with drusen > 125 μm (P[static] = 0.018, P[flicker] = 0.024), drusenoid epithelial detachment (P[static and flicker] < 0.001) and noncentral geographic atrophy (GA; P[static and flicker] < 0.001) had significant reductions in static and flicker sensitivities compared to normal eyes. Static (β-coefficient -1.59, 95% confidence interval [CI] -4.78-1.60) and flicker (β-coefficient -1.29, 95% CI -4.66-2.08) sensitivities declined at a similar rate in eyes that showed clinical signs of progression.
Static and flicker perimetry were affected similarly across the spectrum of AMD severity, and methods appeared to be valid techniques for assessing retinal sensitivity in AMD once drusen > 125 μm are present, but before the development of late AMD.
年龄相关性黄斑变性（AMD）的临床严重程度与黄斑功能之间的关系尚未得到很好的确定。在这项研究中，我们研究了静态和闪烁视野检查检测到的临床严重程度与功能缺陷之间的相关性。
这项横断面研究包括 279 名 AMD 患者和 24 名对照参与者。根据指定研究眼和对侧眼的彩色眼底照片评估结果，AMD 患者被分配到 10 个 AMD 严重程度组之一。在同一次检查中，对一只眼睛进行视力、静态和闪烁视野检查。确定并比较了每个 AMD 严重程度组的静态和闪烁敏感度的几何平均值、标准差和异常眼的百分比。
所有 AMD 严重程度组的静态和闪烁敏感度的敏感性和异常眼百分比的变化模式相似。有 125μm 以上的玻璃膜疣（P[静态] = 0.018，P[闪烁] = 0.024）、类上皮细胞脱离（P[静态和闪烁] < 0.001）和非中心性地图状萎缩（GA；P[静态和闪烁] < 0.001）的眼睛与正常眼睛相比，静态和闪烁敏感度明显降低。与正常眼睛相比，显示临床进展迹象的眼睛的静态（β系数-1.59，95%置信区间[CI]-4.78-1.60）和闪烁（β系数-1.29，95%CI-4.66-2.08）敏感度以相似的速度下降。
在 AMD 严重程度的范围内，静态和闪烁视野检查受到相似的影响，并且一旦存在 125μm 以上的玻璃膜疣，但在晚期 AMD 发生之前，这些方法似乎是评估 AMD 视网膜敏感性的有效技术。
