Phipps Joanna A, Dang Trung M, Vingrys Algis J, Guymer Robyn H
Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia.
Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3355-60. doi: 10.1167/iovs.04-0253.
To compare static and flicker perimetry outcomes in patients with early age-related macular degeneration (AMD).
Perimetry was performed in the central visual field of one eye of each of 25 patients with good visual acuity (> 6/12) and early AMD using static and flickering targets. These results were compared with data obtained from a single eye of 34 age-matched control subjects, 33 of whom were retested at 1 to 3 months after their initial visits.
In all cases, patients with early AMD had greater mean defects for flickering than static targets, returning a significantly larger group average in response to flicker (4.3 +/- 0.6 dB) than to static (1.8 +/- 0.6 dB; P < 0.005). Greater pattern defect losses were also present in AMD-affected eyes with flicker compared with static perimetry (P < 0.02). These give a higher diagnostic sensitivity for flicker (68% vs. 42%, P < 0.05) at 90% specificity. Sensitivity can be increased to 84% +/- 6% (specificity 92% +/- 4%) if the criterion for failure is a more than 10-dB loss in the foveal region (1 degrees -3 degrees ).
Flickering targets expose foveal deficits in early AMD better than do static targets. Flicker perimetry is an easy, short procedure that may be useful for monitoring the progression of AMD.
比较早期年龄相关性黄斑变性（AMD）患者的静态视野检查和闪烁视野检查结果。
使用静态和闪烁视标，对25例视力良好（>6/12）的早期AMD患者的单眼中心视野进行视野检查。将这些结果与34名年龄匹配的对照受试者的单眼数据进行比较，其中33名在初次就诊后1至3个月进行了重新测试。
在所有病例中，早期AMD患者对闪烁视标的平均缺损大于静态视标，对闪烁视标的群体平均反应（4.3±0.6 dB）明显大于静态视标（1.8±0.6 dB；P<0.005）。与静态视野检查相比，受AMD影响的眼睛在闪烁视野检查中也出现了更大的模式缺损损失（P<0.02）。在90%的特异性下，闪烁视野检查的诊断敏感性更高（68%对42%，P<0.05）。如果失败标准是中央凹区域（1°-3°）损失超过10 dB，则敏感性可提高到84%±6%（特异性92%±4%）。
与静态视标相比，闪烁视标能更好地暴露早期AMD患者的中央凹缺陷。闪烁视野检查是一种简单、耗时短的检查方法，可能有助于监测AMD的进展。
