State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Nanjing 210096, P.R. China.
J Biomed Nanotechnol. 2013 Mar;9(3):417-23. doi: 10.1166/jbn.2013.1556.
Poly(L-lactide) acid (PLLA) was mixed with different content of nanoscale-ZnO (N-ZnO) and spun into nonwoven mats by electrospinning, the effects of the blending ratio of N-ZnO on mats morphology and mechanical properties were investigated. The prepared mats were characterized with infrared spectrometry (IR), Brunauer-Emmett-Teller (BET) surface area, the morphology and tensile test were investigated by scanning electron microscope (SEM) and electronic universal testing machine, respectively. The quantity of N-ZnO contained in mats was determinated by Na2 EDTA titration method, then the N-ZnO loading coefficient (%, NL) could be figured out. Infrared spectrometry showed that the electrospun PLLA/N-ZnO mats were prepared successfully. When the concentration of N-ZnO contained in the mats increased from 0 to 2% (w/v), the curves of stress-strain indicated that the elastic modulus of mats ranged among 5.16 to 15.59 MPa. In addition, the electrospun PLLA/N-ZnO exhibited lower cell proliferation for UE7T-13 cells than electrospun PLLA mats and control. The results presented that the N-ZnO added in the mats enhanced the toughness of PLLA/ZnO mats to some extent, though the biocompatibility of blends was not good.
聚（L-丙交酯）酸（PLLA）与不同含量的纳米氧化锌（N-ZnO）混合，并通过静电纺丝纺成无纺垫，研究了 N-ZnO 混合比对垫形态和力学性能的影响。通过红外光谱（IR）、BET 比表面积、扫描电子显微镜（SEM）和电子万能试验机对制备的垫进行了形貌和拉伸试验，分别进行了研究。通过 Na2EDTA 滴定法测定垫中 N-ZnO 的含量，然后计算出 N-ZnO 负载系数（%，NL）。红外光谱表明成功制备了静电纺 PLLA/N-ZnO 垫。当垫中 N-ZnO 的浓度从 0 增加到 2%（w/v）时，应力-应变曲线表明垫的弹性模量在 5.16 到 15.59 MPa 之间。此外，与静电纺 PLLA 垫和对照相比，静电纺 PLLA/N-ZnO 对 UE7T-13 细胞的细胞增殖率较低。结果表明，垫中添加的 N-ZnO 在一定程度上增强了 PLLA/ZnO 垫的韧性，尽管混合物的生物相容性不好。
