Cross J Helen, Guerrini Renzo
Neurosciences Unit, UCL-Institute of Child Health, Great Ormond Street Hospital, London and the Young Epilepsy, Lingfield, UK.
Handb Clin Neurol. 2013;111:619-26. doi: 10.1016/B978-0-444-52891-9.00064-6.
The term epileptic encephalopathy refers to the condition where epileptic activity, clinical or subclinical, is thought to be responsible for any disturbance of cognition, behavior, or motor control. Although currently described as a concept that may occur in any of the epilepsies, children with the severe early onset epilepsies are thought to be more at risk than others. These epilepsies have been termed the "epileptic encephalopathies." The degree to which epileptic activity is responsible for neurodevelopmental compromise may be variable in each individual case, and the degree to which this may be reversible unclear. Data from the laboratory and the clinic may provide greater insight into the degree to which epileptic activity may contribute in individual syndromes, although much is yet to be learnt. The aim in epilepsy management remains one of seizure control; in some specific circumstances this may include subclinical epileptic activity. However, avoidance of treatment that may lead to deterioration of seizure control may be equally important.
术语“癫痫性脑病”指的是这样一种情况：癫痫活动，无论是临床的还是亚临床的，被认为是导致认知、行为或运动控制出现任何障碍的原因。尽管目前将其描述为一种可能出现在任何癫痫类型中的概念，但严重早发性癫痫患儿被认为比其他患儿面临更高风险。这些癫痫类型被称为“癫痫性脑病”。癫痫活动导致神经发育受损的程度在每个个体病例中可能有所不同，而且这种受损的可逆程度尚不清楚。来自实验室和临床的数据可能会让我们更深入地了解癫痫活动在各个综合征中所起作用的程度，尽管仍有许多有待了解。癫痫管理的目标仍然是控制癫痫发作；在某些特定情况下，这可能包括亚临床癫痫活动。然而，避免可能导致癫痫发作控制恶化的治疗同样重要。
