The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, UK.
Cell. 2013 Apr 25;153(3):513-5. doi: 10.1016/j.cell.2013.04.018.
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
组蛋白 H3 赖氨酸 36 的三甲基化（H3K36me3）由 SETD2 完成，与活跃转录区域相关。Li 等人发现 H3K36me3 的一个新作用，即在细胞周期中通过将 MMR 机制靶向染色质来促进细胞中的 DNA 错配修复（MMR），从而解释了某些 MMR 缺陷型癌症的情况。
