各就各位，预备(D2)，跑！H3K36me3 启动 DNA 错配修复。
On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair.
机构信息
The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, UK.
出版信息
Cell. 2013 Apr 25;153(3):513-5. doi: 10.1016/j.cell.2013.04.018.
PMID:23622237
Abstract
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
摘要
组蛋白 H3 赖氨酸 36 的三甲基化（H3K36me3）由 SETD2 完成，与活跃转录区域相关。Li 等人发现 H3K36me3 的一个新作用，即在细胞周期中通过将 MMR 机制靶向染色质来促进细胞中的 DNA 错配修复（MMR），从而解释了某些 MMR 缺陷型癌症的情况。
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