Graduate Institute of Medical Sciences, Department of Physiology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Atherosclerosis. 2013 Jun;228(2):406-12. doi: 10.1016/j.atherosclerosis.2013.03.032. Epub 2013 Apr 8.
Previous investigations have revealed an association between the ABO locus/blood group and total cholesterol and inflammatory biomarker levels. We aimed to test the statistical association of ABO locus variants with lipid profiles and levels of thirteen inflammatory markers in a Taiwanese population.
A sample population of 617 Taiwanese subjects was enrolled. Five ABO gene region polymorphisms were selected and genotyped. After adjusting for clinical covariates and inflammatory marker levels, the genetic-inferred ABO blood group genotypes were associated with sE-selectin level (P = 3.5 × 10(-36)). Significantly higher total and low-density lipoprotein cholesterol (LDL-C) levels were noted in individuals with blood group A (P = 7.2 × 10(-4) and P = 7.3 × 10(-4), respectively). Interestingly, after adjusting for sE-selectin level, significantly lower high-density lipoprotein cholesterol (HDL-C) level as well as higher triglyceride (TG) level and ratio of triglyceride to HDL-C (TG/HDL-C ratio) were noted in individuals with blood group A comparing to non-A individuals (P = 0.009, P = 0.004 and P = 0.001, respectively); these associations were also observed in the group A male subjects (P = 0.027, P = 0.001, and P = 0.002, respectively). Mediation analysis further revealed a suppression effect of sE-selectin level on the association between genetic-inferred ABO blood group genotypes and TG/HDL-C ratio in total participants (P = 1.18 × 10(-6)) and in males (P = 5.99 × 10(-5)).
Genetic variants at the ABO locus independently affect sE-selectin level in Taiwanese subjects, while the association of ABO locus variants with TG/HDL-C ratio is suppressed by sE-selectin level in Taiwanese males. These results provided further evidence for the mechanism in the association of ABO blood groups with atherosclerotic cardiovascular diseases.
先前的研究表明 ABO 基因座/血型与总胆固醇和炎症生物标志物水平之间存在关联。我们旨在检验 ABO 基因座变异与台湾人群脂质谱和 13 种炎症标志物水平的统计学关联。
纳入了 617 名台湾受试者的样本人群。选择并基因分型了五个 ABO 基因区域多态性。在调整临床协变量和炎症标志物水平后，遗传推断的 ABO 血型基因型与 sE-选择素水平相关（P=3.5×10(-36)）。与非 A 血型个体相比，A 血型个体的总胆固醇和低密度脂蛋白胆固醇（LDL-C）水平显著升高（P=7.2×10(-4)和 P=7.3×10(-4)）。有趣的是，在调整 sE-选择素水平后，与非 A 血型个体相比，A 血型个体的高密度脂蛋白胆固醇（HDL-C）水平显著降低，甘油三酯（TG）水平和 TG/HDL-C 比值升高（P=0.009、P=0.004 和 P=0.001）；在 A 型男性中也观察到这些关联（P=0.027、P=0.001 和 P=0.002）。中介分析进一步表明，在总参与者（P=1.18×10(-6))和男性参与者（P=5.99×10(-5))中，sE-选择素水平对遗传推断的 ABO 血型基因型与 TG/HDL-C 比值之间的关联具有抑制作用。
ABO 基因座的遗传变异独立影响台湾人群的 sE-选择素水平，而 ABO 基因座变异与 TG/HDL-C 比值的关联在台湾男性中受到 sE-选择素水平的抑制。这些结果为 ABO 血型与动脉粥样硬化性心血管疾病关联的机制提供了进一步的证据。
