Department of Physics and Astronomy, Washington State University, Pullman, WA 99164, USA.
Mater Sci Eng C Mater Biol Appl. 2013 Jul 1;33(5):3061-8. doi: 10.1016/j.msec.2013.03.043. Epub 2013 Apr 1.
Influence of pentavalent tantalum doping in bulk hydroxyapatite (HAp) ceramics has been investigated for polarizability and bioactivity. Phase analysis from X-ray diffraction measurement indicates that increasing dopant concentration decreased the amount of HAp phase and increased β-TCP and/or α-TCP phases during sintering at 1250 °C in a muffle furnace. Results from thermally stimulated depolarization current (TSDC) measurements showed that doping hindered charge storage ability in HAp ceramics, and doped samples stored fewer charge compared to pure HAp. However, doping enhanced wettability of HAp samples, which was improved further due to polarization. In vitro human osteoblast cell-material interaction study revealed an increase in bioactivity due to dopant addition and polarization compared to pure HAp. This increase in bioactivity was attributed to the increase in wettability due to surface charge and dopant addition.
五价钽掺杂对块状羟基磷灰石（HAp）陶瓷的极化率和生物活性的影响进行了研究。X 射线衍射测量的相分析表明，在马弗炉中 1250°C 烧结时，随着掺杂浓度的增加，HAp 相的含量减少，β-TCP 和/或 α-TCP 相的含量增加。热刺激去极化电流（TSDC）测量结果表明，掺杂阻碍了 HAp 陶瓷的电荷存储能力，与纯 HAp 相比，掺杂样品存储的电荷更少。然而，掺杂增强了 HAp 样品的润湿性，由于极化作用，润湿性进一步提高。体外人成骨细胞-材料相互作用研究表明，与纯 HAp 相比，由于掺杂和极化作用，生物活性增加。这种生物活性的增加归因于表面电荷和掺杂剂增加引起的润湿性增加。
