School of Social Work, University of Pittsburgh, 2117 Cathedral of Learning, Pittsburgh, PA 15260, USA.
Psychiatry Res. 2013 Aug 30;209(1):21-6. doi: 10.1016/j.psychres.2013.03.020. Epub 2013 Apr 23.
Cognitive rehabilitation has shown beneficial effects on cognition in patients with schizophrenia, which may also help to improve negative symptoms due to overlapping pathophysiology between these two domains. To better understand the possible relationship between these areas, we conducted an exploratory analysis of the effects of Cognitive Enhancement Therapy (CET) on negative symptoms. Early course schizophrenia outpatients (n=58) were randomized to 2 years of CET or an Enriched Supportive Therapy (EST) control condition. Results revealed significant and medium-sized (d=0.61) differential improvements favoring CET in overall negative symptoms, particularly social withdrawal, affective flattening, and motor retardation. Neurocognitive improvement was associated with reduced negative symptoms in CET, but not EST patients. No relationships were observed between improvements in emotion processing aspects of social cognition, as measured by the Mayer-Salovey-Caruso Emotional Intelligence Test, and negative symptoms. CET represents an effective cognitive rehabilitation intervention for schizophrenia that may also have benefits to negative symptoms. Future studies specifically designed to examine negative symptoms during the course of cognitive rehabilitation are needed.
认知康复已显示出对精神分裂症患者认知的有益影响，由于这两个领域的病理生理学重叠，这也可能有助于改善阴性症状。为了更好地理解这两个领域之间的可能关系，我们对认知增强治疗（CET）对阴性症状的影响进行了探索性分析。早期精神分裂症门诊患者（n=58）随机分为 2 年 CET 或丰富支持性治疗（EST）对照组。结果显示，CET 组在总体阴性症状，特别是社交退缩、情感迟钝和运动迟缓方面，有显著的、中等程度的（d=0.61）改善，明显优于 EST 组。认知改善与 CET 患者的阴性症状减少相关，但与 EST 患者无关。在 Mayer-Salovey-Caruso 情绪智力测试测量的社会认知的情绪处理方面的改善与阴性症状之间没有观察到关系。CET 是一种有效的精神分裂症认知康复干预措施，也可能对阴性症状有益。需要进行专门设计的研究，以在认知康复过程中检查阴性症状。
