Combillet F, Rougier M-B, Blaizeau M, Korobelnik J-F, Delyfer M-N
Unité rétine, uvéite et neuro-ophtalmologie, service d'ophtalmologie, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
J Fr Ophtalmol. 2013 Oct;36(8):652-7. doi: 10.1016/j.jfo.2012.08.012. Epub 2013 Apr 25.
Multiple evanescent white dot syndrome (MEWDS) is a rare, usually unilateral, retinal disease associated with transient loss of vision. Its pathogenesis remains elusive. The purpose of this study was to determine the spatial location of the lesions in the neurosensory retina of a patient with MEWDS, using a new technology, i.e. "en face" optical coherence tomography ("en face" OCT).
A 21-year-old woman presenting with bilateral MEWDS underwent Cirrus(®) OCT with advanced "en face" reconstructions of the various retinal layers and inner choroid, fluorescein angiography, and infracyanine green angiography (ICGA).
During the acute stage of MEWDS, advanced "en face" visualization mode of the IS/OS photoreceptor junction and the inner choroid showed areas of strong signal attenuation, forming a spot pattern identical to that of the hypofluorescent IGCA dots. One month later, visual acuity returned to 20/25 in both eyes and the reflectivity map of the IS/OS junction and inner choroid displayed no areas of signal attenuation.
"En face" OCT is a new, noninvasive technology, capable of visualizing specific attenuation of the IS/OS junction in MEWDS, which form a spot pattern identical to those revealed by ICGA.
多发性一过性白点综合征（MEWDS）是一种罕见的、通常为单侧性的视网膜疾病，与视力短暂丧失有关。其发病机制尚不清楚。本研究的目的是使用一种新技术，即“正面”光学相干断层扫描（“正面”OCT），确定一名MEWDS患者神经感觉视网膜中病变的空间位置。
一名患有双侧MEWDS的21岁女性接受了Cirrus（®）OCT检查，对视网膜各层和脉络膜内层进行了先进的“正面”重建、荧光素血管造影和吲哚青绿血管造影（ICGA）。
在MEWDS急性期，IS/OS光感受器连接和脉络膜内层的先进“正面”可视化模式显示出强信号衰减区域，形成与低荧光ICGA点相同的点状图案。一个月后，双眼视力恢复到20/25，IS/OS连接和脉络膜内层的反射率图未显示信号衰减区域。
“正面”OCT是一种新的非侵入性技术，能够显示MEWDS中IS/OS连接的特定衰减，其形成的点状图案与ICGA显示的相同。
