Departments of Medicine & Neuroscience, Albert Einstein College of Medicine, Diabetes Research and Training Center, New York Obesity Research Center, USA.
Appetite. 2013 Dec;71:466-9. doi: 10.1016/j.appet.2013.04.017. Epub 2013 Apr 25.
The adiposity hormone leptin has been implicated in the regulation of behavioral and metabolic controls of body weight. Leptin receptors are found in multiple peripheral and central tissues, particularly within hypothalamic and brainstem neuronal populations. Central leptinergic signaling acts as an indirect control to modulate the feeding inhibitory potency of the direct controls of meal size. Mouse models of neuronal leptin loss and gain of function have helped to identify and characterize how central leptin contributes to the central control of food intake.
肥胖激素瘦素参与了行为和代谢控制体重的调节。瘦素受体存在于多个外周和中枢组织中，特别是在下丘脑和脑干神经元群体中。中枢瘦素能信号作为一种间接控制，调节直接控制进食量的进食抑制作用。神经元瘦素缺失和功能获得的小鼠模型有助于确定和描述中枢瘦素如何有助于食物摄入的中枢控制。
