Department of Chemistry, National Dong-Hwa University, Hualien 974, Taiwan.
Molecules. 2013 Apr 26;18(5):4972-85. doi: 10.3390/molecules18054972.
The crystal structure of a naturally occurring cyclic tetrapeptide cyclo(Gly-L-Ser-L-Pro-L-Glu) [cyclo(GSPE)] was obtained. The conformation of synthesized cyclo(GSPE) fixes the coordination to lead ion in a 1:1 ratio. This cyclo(GSPE)-Pb complex was constructed as an asymmetric 3D network in the crystalline state. The polymerization of a heavy metal ion with a rigid asymmetric cyclic tetrapeptide represents the first example of a new class of macrocyclic complexes.
天然存在的环状四肽环（甘氨酰-L-丝氨酰-L-脯氨酰-L-谷氨酸）[环（GSPE）]的晶体结构已被获得。合成的环（GSPE）的构象以 1:1 的比例固定了与铅离子的配位。该环（GSPE）-Pb 配合物在晶体状态下构建为不对称的 3D 网络。刚性不对称环状四肽与重金属离子的聚合代表了一类新的大环配合物的首例。
