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Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment.

作者信息

Chakraborty Saumen, Kravitz Joslyn Yudenfreund, Thulstrup Peter W, Hemmingsen Lars, DeGrado William F, Pecoraro Vincent L

机构信息

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Angew Chem Int Ed Engl. 2011 Feb 25;50(9):2049-53. doi: 10.1002/anie.201006413. Epub 2011 Feb 15.

DOI:10.1002/anie.201006413
PMID:21344549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3058785/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0340/3058785/1ff5e78094ac/nihms-276593-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0340/3058785/45f03a85dc52/nihms-276593-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0340/3058785/1ff5e78094ac/nihms-276593-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0340/3058785/45f03a85dc52/nihms-276593-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0340/3058785/1ff5e78094ac/nihms-276593-f0002.jpg

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本文引用的文献

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Controlling and fine tuning the physical properties of two identical metal coordination sites in de novo designed three stranded coiled coil peptides.控制和微调从头设计的三股螺旋卷曲肽中两个相同金属配位位点的物理性质。
J Am Chem Soc. 2011 Jan 19;133(2):239-51. doi: 10.1021/ja104433n. Epub 2010 Dec 16.
2
Structural comparisons of apo- and metalated three-stranded coiled coils clarify metal binding determinants in thiolate containing designed peptides.无金属状态和金属化三股螺旋卷曲螺旋的结构比较阐明了含硫醇设计肽中的金属结合决定因素。
J Am Chem Soc. 2010 Sep 29;132(38):13240-50. doi: 10.1021/ja101812c.
3
An artificial di-iron oxo-protein with phenol oxidase activity.一种具有酚氧化酶活性的人工双铁氧代蛋白。
Nat Chem Biol. 2009 Dec;5(12):882-4. doi: 10.1038/nchembio.257. Epub 2009 Nov 8.
4
Design of functional metalloproteins.功能性金属蛋白的设计
Nature. 2009 Aug 13;460(7257):855-62. doi: 10.1038/nature08304.
5
Harnessing natures ability to control metal ion coordination geometry using de novo designed peptides.利用自然界通过从头设计的肽来控制金属离子配位几何结构的能力。
Dalton Trans. 2009 Apr 7(13):2271-80. doi: 10.1039/b818306f. Epub 2009 Jan 16.
6
The correlation of 113Cd NMR and 111mCd PAC spectroscopies provides a powerful approach for the characterization of the structure of Cd(II)-substituted Zn(II) proteins.113Cd核磁共振与111mCd正电子湮没符合辐射谱学的相关性为表征Cd(II)取代的Zn(II)蛋白质的结构提供了一种强大的方法。
Chemistry. 2009;15(15):3761-72. doi: 10.1002/chem.200802105.
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The application of (199)Hg NMR and (199m)Hg perturbed angular correlation (PAC) spectroscopy to define the biological chemistry of Hg(II): a case study with designed two- and three-stranded coiled coils.应用（199）汞核磁共振和（199m）汞扰动角关联（PAC）光谱法确定汞（II）的生物化学性质：以设计的双链和三链卷曲螺旋为例的研究
Chemistry. 2007;13(33):9178-90. doi: 10.1002/chem.200701208.
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Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils.利用设计的三链卷曲螺旋结构鉴定抗砷蛋白的重要结构特征。
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