Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
J Neurooncol. 2013 Jul;113(3):359-63. doi: 10.1007/s11060-013-1134-2. Epub 2013 Apr 29.
Myxopapillary ependymoma (MPE) is a rare tumor of the distal spinal cord. Despite benign histopathology, local recurrences occur in ~30 % of patients and distant metastases have been described in few cases. MPE tumor cells typically express glial fibrillary acidic protein (GFAP), which could be released to the circulation. In this current report, we investigated circulating plasma-GFAP in a series of MPE patients. We analyzed circulating plasma-GFAP using a commercially available ELISA kit in 3 patients with completely resected MPE, 1 patient with locally advanced MPE and 2 patients with pleuropulmonary metastases of MPE. As controls we used blood samples of age and gender-matched healthy volunteers (n = 3), 6 glioblastoma patients with known plasma-GFAP status (positive for 3 and negative for 3 patients) and 3 brain metastases patients with known plasma-GFAP negativity. We found very high concentrations of plasma-GFAP in two MPE patients with pleuropulmonary metastases, while in none of the other MPE patients circulating plasma-GFAP was detectable. Circulating GFAP could be useful as marker for early detection or follow-up of distant metastases in MPE patients.
黏液性乳头状室管膜瘤（MPE）是一种罕见的脊髓远端肿瘤。尽管组织病理学表现为良性，但约 30%的患者会出现局部复发，少数病例还出现远处转移。MPE 肿瘤细胞通常表达胶质纤维酸性蛋白（GFAP），这种蛋白可能会释放到血液中。在本研究中，我们检测了一系列 MPE 患者的循环血浆-GFAP。我们使用商业上可获得的 ELISA 试剂盒分析了 3 例完全切除的 MPE 患者、1 例局部晚期 MPE 患者和 2 例 MPE 胸膜肺转移患者的循环血浆-GFAP。作为对照，我们使用了年龄和性别匹配的健康志愿者的血液样本（n = 3）、6 例已知血浆-GFAP 状态的胶质母细胞瘤患者（3 例阳性和 3 例阴性）和 3 例已知血浆-GFAP 阴性的脑转移瘤患者。我们发现，2 例 MPE 胸膜肺转移患者的血浆-GFAP 浓度非常高，而其他 MPE 患者的循环血浆-GFAP 均无法检测到。循环 GFAP 可作为 MPE 患者早期检测或随访远处转移的标志物。
