1.University Medical Center Utrecht, HP. E 03.511, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.
J Leukoc Biol. 2013 Oct;94(4):595-601. doi: 10.1189/jlb.1112571. Epub 2013 Apr 26.
Neutrophils are the most abundant white blood cells and are indispensable for host defense. Recently, they have also been implicated in immune regulation and suppression. The latter functions seem hard to reconcile with the widely held view that neutrophils are very short-lived, with a circulatory half-life of <7 h. To reopen the discussion on the average neutrophil half-life, we review and discuss experiments performed in the 1950s, 1960s, and 1970s, as well as recent in vivo labeling experiments. We reappraise the current knowledge on neutrophil half-lives, including their production in the bone marrow, their residency in the circulation and marginated pool, and their exit from the circulation.
中性粒细胞是最丰富的白细胞，对于宿主防御是不可或缺的。最近，它们也被牵连到免疫调节和抑制中。后一种功能似乎很难与普遍认为的中性粒细胞寿命很短（循环半衰期<7 小时）相协调。为了重新讨论平均中性粒细胞半衰期，我们回顾和讨论了 20 世纪 50 年代、60 年代和 70 年代进行的实验，以及最近的体内标记实验。我们重新评估了目前关于中性粒细胞半衰期的知识，包括它们在骨髓中的产生、在循环和边缘池中停留以及从循环中排出。
