Nawaz Asif, Jan Syed Umer, Khan Nauman Rahim, Hussain Abid, Khan Gul Majid
Department of Pharmaceutics, Faculty of Pharmacy Gomal University, Dera Ismail Khan, KPK, Pakistan.
Pak J Pharm Sci. 2013 May;26(3):617-22.
Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermal and transdermal products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to develop Clotrimazole gel and to evaluate the effect of almond oil and tween 80 (in different concentrations), on the permeation of drug through rabbit skin in vitro. In order to investigate the effect of penetration enhancers used in this study on the permeation of Clotrimazole through sections of excised rabbit skin, Franz diffusion cell was employed. Sample solution was withdrawn at specific time interval up to 24 h. Significant difference in permeation among the eight formulations was seen in the study. The permeation profile of various formulations also showed that the added enhancers in individual batches affected the permeation of the drug. Drug permeation increased with increased concentration of Tween 80 and decreased concentration of almond oil. Furthermore, almond oil combined with tween 80 showed synergistic effect. The clotrimazole gels were successfully formulated and could be beneficial for topical use.
实现药物分子理想的经皮吸收是皮肤和透皮产品配方设计中的一个主要关注点。使用渗透促进剂可为实现这一目的提供一种成功的方法。本研究的目的是开发克霉唑凝胶，并评估杏仁油和吐温80（不同浓度）对药物体外透过兔皮肤的影响。为了研究本研究中使用的渗透促进剂对克霉唑透过切除的兔皮肤切片的渗透作用，采用了Franz扩散池。在长达24小时的特定时间间隔内抽取样品溶液。研究中观察到八种制剂之间的渗透存在显著差异。各种制剂的渗透曲线还表明，各批次中添加的促进剂影响了药物的渗透。药物渗透率随吐温80浓度的增加和杏仁油浓度的降低而增加。此外，杏仁油与吐温80联合使用显示出协同作用。成功制备了克霉唑凝胶，其对局部应用可能有益。
