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在负载下,纺织盆底植入物的延长与有效孔隙率的完全丧失有关,从而有利于与疤痕板结合。

Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates.

机构信息

Department for General, Visceral and Transplant Surgery at the University Hospital of the RWTH Aachen, Germany.

出版信息

J Biomed Mater Res A. 2014 Apr;102(4):1079-84. doi: 10.1002/jbm.a.34767. Epub 2013 Jun 11.

DOI:10.1002/jbm.a.34767
PMID:23625516
Abstract

Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices has to include the impact of strain on stretchability and effective porosity. Prolift(®) and Prolift + M(®), developed for tension free conditions, were tested by measuring stretchability and effective porosity applying mechanical strain. For comparison, we used Dynamesh-PR4(®), which was designed for pelvic floor repair to withstand mechanical strain. Prolift(®) at rest showed moderate porosity with little stretchability but complete loss of effective porosity at strain of 4.9 N/cm. Prolift + M(®) revealed an increased porosity at rest, but at strain showed high stretchability, with subsequent loss of effective porosity at strain of 2.5 N/cm. Dynamesh PR4(®) preserved its high porosity even under strain, but as consequence of limited stretchability. Though in tension free conditions Prolift(®) and Prolift + M(®) can be considered as large pore class I meshes, application of mechanical strain rapidly lead to collapse of pores. The loss of porosity at mechanical stress can be prevented by constructions with high structural stability. Assessment of porosity under strain was found helpful to define requirements for pelvic floor devices. Clinical studies have to prove whether devices with high porosity as well as high structural stability can improve the patients' outcome.

摘要

用于增强盆底结构的纺织结构的使用必须考虑到植入物的机械力,这些机械力与腹壁的无张力条件有很大的不同。因此,纺织器械的生物力学分析必须包括应变对可拉伸性和有效孔隙率的影响。Prolift(®)和 Prolift + M(®)是为无张力条件开发的,通过测量拉伸性和有效孔隙率来测试机械应变。为了进行比较,我们使用了 Dynamesh-PR4(®),它是专门为承受机械应变而设计的用于盆底修复的器械。在静止状态下,Prolift(®)的孔隙率适中,可拉伸性差,但在 4.9 N/cm 的应变下有效孔隙率完全丧失。Prolift + M(®)在静止时表现出增加的孔隙率,但在应变下表现出高可拉伸性,随后在 2.5 N/cm 的应变下有效孔隙率丧失。Dynamesh PR4(®)即使在应变下也能保持其高孔隙率,但由于可拉伸性有限。尽管在无张力条件下,Prolift(®)和 Prolift + M(®)可以被认为是大孔径 I 类网,但机械应变的应用会迅速导致孔的塌陷。通过具有高结构稳定性的结构可以防止在机械应力下孔隙率的损失。在应变下评估孔隙率有助于确定盆底器械的要求。临床研究必须证明具有高孔隙率和高结构稳定性的器械是否可以改善患者的预后。

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