Mühl Thomas, Binnebösel Marcel, Klinge Uwe, Goedderz Thomas
Aachen University of Applied Sciences, Department of Electrical Engineering and Information Technology, Eupener Str. 70, 52066 Aachen, Germany.
J Biomed Mater Res B Appl Biomater. 2008 Jan;84(1):176-83. doi: 10.1002/jbm.b.30859.
The inflammatory and fibrotic intensity of a foreign body reaction largely depends on the porosity of the implanted material. Furthermore, the size of the pore and its geometry define the capability to allow tissue ingrowth. We present an image analysis system, which allows objectifying in two dimensions the pores' structure and geometry of textile fabrics, that are used to reinforce the abdominal wall or pelvic floor. The porosity of the textile is measured at four samples with differences in structure. The porosity decreases markedly if foreign body response is considered, leading to the definition of an "effective porosity". Because of the high stiffness of the polymer fibers the elasticity of textile implants usually result from a deformation of the pores, leading to a marked reduction of the effective porosity if a mechanical stress is applied. Further in vivo studies have to investigate, whether the preservation of a high effective porosity under stress may help to improve biocompatibility of textile implants.
异物反应的炎症和纤维化强度在很大程度上取决于植入材料的孔隙率。此外,孔隙的大小及其几何形状决定了组织向内生长的能力。我们提出了一种图像分析系统,该系统能够在二维层面客观化用于加强腹壁或盆底的纺织织物孔隙的结构和几何形状。在四个结构不同的样本上测量了织物的孔隙率。如果考虑异物反应,孔隙率会显著降低,从而定义了“有效孔隙率”。由于聚合物纤维的高刚度,纺织植入物的弹性通常源于孔隙的变形,因此在施加机械应力时有效孔隙率会显著降低。进一步的体内研究必须调查,在应力作用下保持高有效孔隙率是否有助于提高纺织植入物的生物相容性。